In acute kidney injury (AKI), renal function declines rapidly over hours to days, and affected dogs and cats become acutely ill. Prompt diagnosis and treatment can prevent or minimize permanent renal damage. If affected renal tissue is not irreversibly damaged, patients maintained with supportive care may regain sufficient renal function to sustain normal life.
Risk factors for AKI include:
- Increasing age
- Preexisting/subclinical chronic kidney disease (CKD)
- Adverse drug combinations (eg, gentamicin/furosemide1; amphotericin/furosemide2)
- Prolonged anesthesia (especially with concurrent NSAIDs)3
- Dehydration, hypovolemia, hypotension