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(Rimadyl, Generics)

Nonsteroidal Anti-Inflammatory Agent (Systemic Drug)

Prescriber Highlights

  • An NSAID used primarily in dogs
  • Used with caution in geriatric patients or patients with chronic disease (eg, liver or kidney disease, GI disease)
  • Most common side effect is GI upset; GI ulceration and liver and kidney failure may occur, although rarely 
  • Monitoring of liver and kidney values is recommended

Uses, Indications

  • Labeled for relief of pain and inflammation in dogs
  • Has potential use as adjunctive treatment for certain types of cancer

Contraindications, Precautions, Warnings

  • Contraindications
    Patients with bleeding disorders or sensitivity to other anti-inflammatory agents
  • Precautions
    Hepatic or renal insufficiency
  • Warnings
    Not for use in dogs younger than 6 weeks, pregnant or lactating bitches, or dogs used for breeding purposes

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Side Effects

  • GI signs (eg, vomiting, inappetence) and lethargy are most common
  • More serious side effects (eg, GI ulceration, hepatocellular damage, renal disease) are rare

Drug Interactions

  • Do not give to patients concurrently receiving other ulcerogenic drugs (eg, steroids, other NSAIDs)
  • For a full list of drug interactions, visit


  • Baseline CBC, serum chemistry profile, and urinalysis
  • Monitor liver enzymes every 1, 2, and 4 weeks of therapy and then at 3- and 6-month intervals if used long-term
  • Signs of adverse events include GI upset, increased thirst and urination, anemia, jaundice, ataxia, and seizures

Client Information

  • Giving with food may help reduce GI upset
  • Most dogs tolerate the medication well; however, it is important to monitor for signs of kidney or liver failure (eg, changes in appetite, drinking, bowel movements, behavior, energy level; vomiting; yellowing of gums)
  • Periodic laboratory tests monitoring liver and kidney function are recommended

Dosage Forms

  • Available tablet sizes: 25 mg, 75 mg, and 100 mg
  • Injectable: 50 mg/ml

–Compiled and summarized from Plumb’s Veterinary Drugs by Shannon Palermo, VMD

Information about this drug was adapted from Plumb’s Veterinary Drugs. Further details and more therapeutics can be found with a subscription at

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