Grapiprant

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Grapiprant

Non-Steroidal Anti-Inflammatory Medication (Systemic Drug)

Prescriber Highlights

  • Prostaglandin E2 EP4-receptor antagonist (systemic drug), a new class of NSAID for treating osteoarthritis pain in dogs that does not inhibit cyclooxygenase (COX)
  • Potentially causes fewer severe adverse effects in dogs than other NSAIDs
  • GI effects (eg, vomiting, diarrhea) possible
Uses, Indications
  • Approved for control of pain and inflammation associated with osteoarthritis in dogs
Contraindications, Warnings
  • Contraindications

Patients with hypersensitivity to grapiprant or its components

  • Warnings
    • Grapiprant has not been evaluated in dogs younger than 9 months of age or weighing less than 8 lbs (3.6 kgs)
    • Safe use has not been established in dogs used for breeding or in pregnant or lactating dogs
Side Effects
  • GI distress (eg, vomiting; diarrhea; decreased appetite; mucoid, watery, or bloody stools)
  • Decreased serum albumin and total protein
Drug Interactions
  • Grapiprant is a substrate of P-glycoprotein transport, but no clinically relevant drug interactions have been identified
  • No inhibition of metabolic pathways mediated by cytochrome P450 isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, or CYP3A4
  • Concurrent use with other anti-inflammatory drugs (eg, COX-inhibiting NSAIDs, corticosteroids) should be avoided
  • Washout period suggested when switching from corticosteroids or COX-inhibiting NSAIDs to grapiprant
Monitoring
  • Clinical efficacy, adverse events
  • Appetite
  • Emesis
  • Stool characteristics
Client Information
  • May be given with or without food; however, if vomiting occurs, give with food
  • Most common adverse effects include vomiting, diarrhea, and decreased appetite
Dosage Forms
  • Grapiprant flavored tablets: 20 mg, 60 mg, and 100 mg

Compiled and summarized from Plumb’s® Veterinary Drugs by Shannon Palermo, VMD

Information about this drug was adapted from Plumb’s® Veterinary Drugs. Further details and more therapeutics can be found with a subscription at plumbsveterinarydrugs.com

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