Sign in to Print/View PDF


Non-Steroidal Anti-Inflammatory Medication (Systemic Drug)

Prescriber Highlights

  • Prostaglandin E2 EP4-receptor antagonist (systemic drug), a new class of NSAID for treating osteoarthritis pain in dogs that does not inhibit cyclooxygenase (COX)
  • Potentially causes fewer severe adverse effects in dogs than other NSAIDs
  • GI effects (eg, vomiting, diarrhea) possible
Uses, Indications
  • Approved for control of pain and inflammation associated with osteoarthritis in dogs
Contraindications, Warnings
  • Contraindications

Patients with hypersensitivity to grapiprant or its components

  • Warnings
    • Grapiprant has not been evaluated in dogs younger than 9 months of age or weighing less than 8 lbs (3.6 kgs)
    • Safe use has not been established in dogs used for breeding or in pregnant or lactating dogs
Side Effects
  • GI distress (eg, vomiting; diarrhea; decreased appetite; mucoid, watery, or bloody stools)
  • Decreased serum albumin and total protein
Drug Interactions
  • Grapiprant is a substrate of P-glycoprotein transport, but no clinically relevant drug interactions have been identified
  • No inhibition of metabolic pathways mediated by cytochrome P450 isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, or CYP3A4
  • Concurrent use with other anti-inflammatory drugs (eg, COX-inhibiting NSAIDs, corticosteroids) should be avoided
  • Washout period suggested when switching from corticosteroids or COX-inhibiting NSAIDs to grapiprant
  • Clinical efficacy, adverse events
  • Appetite
  • Emesis
  • Stool characteristics
Client Information
  • May be given with or without food; however, if vomiting occurs, give with food
  • Most common adverse effects include vomiting, diarrhea, and decreased appetite
Dosage Forms
  • Grapiprant flavored tablets: 20 mg, 60 mg, and 100 mg

Compiled and summarized from Plumb’s® Veterinary Drugs by Shannon Palermo, VMD

Information about this drug was adapted from Plumb’s® Veterinary Drugs. Further details and more therapeutics can be found with a subscription at

Material from Veterinary Team Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.

Practice Tools

Veterinary Team Brief delivers practical skills for team-based medicine—with clinical strategies for team training, peer-reviewed credibility, concise content, essential training modules, and easy-to-implement protocols. From the publisher of Clinician's Brief.

© 2018 Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Privacy Policy (Updated 05/08/2018) Terms of Use (Updated 05/08/2018)